Table III.
Relationships between mRNA levels and clinical characteristics.
Characteristic | Statistics | BRCA1 | TYMS | STMN1 | TOP2A | PDGFR | VEGFR2 | KIT | HER2 |
---|---|---|---|---|---|---|---|---|---|
Gender | χ2 | 3.042 | 7.846 | 0.255 | 5.702 | 1.318 | 0.255 | 1.771 | 0.008 |
P-value | 0.081 | 0.005 | 0.614 | 0.017 | 0.251 | 0.614 | 0.183 | 0.927 | |
Age (years) | χ2 | 0.124 | 0.006 | 0.006 | 0.006 | 3.176 | 0.006 | 3.200 | 0.608 |
P-value | 0.725 | 0.939 | 0.939 | 0.939 | 0.075 | 0.939 | 0.074 | 0.436 | |
Stage | χ2 | 1.455 | 1.769 | 4.989 | 3.949 | 0.626 | 9.081 | 10.277 | 8.388 |
P-value | 0.693 | 0.622 | 0.173 | 0.267 | 0.890 | 0.028 | 0.016 | 0.039 | |
Primary tumor | χ2 | 4.832 | 1.482 | 4.314 | 3.665 | 3.829 | 6.149 | 10.267 | 1.799 |
P-value | 0.185 | 0.686 | 0.230 | 0.300 | 0.281 | 0.105 | 0.016 | 0.615 | |
Lymph nodes | χ2 | 3.692 | 7.394 | 0.839 | 5.162 | 3.622 | 0.353 | 1.385 | 1.073 |
P-value | 0.297 | 0.060 | 0.840 | 0.160 | 0.305 | 0.950 | 0.709 | 0.784 | |
Distant metastasis | χ2 | 0.036 | 0.095 | 0.036 | 0.653 | 0.328 | 7.222 | 1.709 | 4.183 |
P-value | 0.849 | 0.758 | 0.849 | 0.419 | 0.567 | 0.007 | 0.191 | 0.041 | |
Histological type | χ2 | 16.481 | 8.074 | 1.831 | 5.713 | 1.075 | 1.075 | 3.255 | 6.618 |
P-value | 0.000 | 0.004 | 0.176 | 0.017 | 0.300 | 0.300 | 0.071 | 0.010 | |
Differentiation | χ2 | 1.462 | 5.942 | 5.544 | 0.795 | 0.443 | 0.443 | 4.043 | 5.427 |
P-value | 0.481 | 0.051 | 0.063 | 0.672 | 0.801 | 0.801 | 0.132 | 0.066 | |
Smoking history | χ2 | 6.867 | 5.888 | 0.268 | 8.106 | 4.988 | 0.507 | 1.357 | 0.085 |
P-value | 0.009 | 0.015 | 0.605 | 0.004 | 0.026 | 0.476 | 0.244 | 0.771 |
Statistics were calculated by the χ2 test and the undetermined samples were not included. The cut-off point of the primary tumor was 3 cm. BRCA1, breast cancer 1; TYMS, thymidylate synthetase; STMN1, stathmin 1; TOP2A, topoisomerase II α; VEGFR2, vascular endothelial growth factor receptor 2; PDGFR, platelet-derived growth factor receptor; HER2, human epidermal growth factor receptor 2.