Table VII.

Evaluation of side effects by the visual analog scale.

A, Headachea,b
Temperature	Cycle 1	Cycle 2	Cycle 3	Cycle 4
3°C	0.8 (1.0)	0.9 (1.4)	1.0 (2.3)	0.3 (0.3)
8°C	0.5 (0.6)	0.3 (0.3)	0.4 (0.2)	0.3 (0.2)
P-valued	0.193	0.124	0.298	0.662
B, Coldnessa,c
Temperature	Cycle 1	Cycle 2	Cycle 3	Cycle 4
3°C	2.7 (2.3)	3.0 (2.5)	3.0 (2.8)	3.4 (2.4)
8°C	1.8 (1.8)	1.6 (1.5)	1.9 (1.8)	2.5 (2.6)
P-valued	0.175	0.061	0.207	0.320

^aMean visual analog scale (VAS) score (SD). The evaluation of the VAS score was performed after the administration of chemotherapy.

^bANOVA repeated measures; 3°C vs. 8°C, P=0.085.

^cANOVA repeated measures; 3°C vs. 8°C, P=0.037.

^dStudent’s t-test. SD, standard deviation.