Table 3.
Significant single nucleotide polymorphism–education interactions
| SNP rs no. | Chr | Location | Type | MAF | Trait | Covariable | Beta (Main) | SE (Main) | Beta (Int) | SE (Int) | P value 1 df interaction | P value 2 df interaction |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs12113527 | 7 | PTN intron | Imp | 0.044 | SBP | Comp_BA | −5.40 | 0.98 | 7.05 | 1.29 | 4.28E-08 | 2.86E-08 |
| rs12536916 | 7 | PTN intron | Imp | 0.044 | SBP | Comp_BA | −5.30 | 0.98 | 6.97 | 1.29 | 5.83E-08 | 4.61E-08 |
| rs6979228 | 7 | PTN intron | Imp | 0.044 | SBP | Comp_BA | −5.30 | 0.98 | 6.97 | 1.28 | 5.81E-08 | 4.58E-08 |
| rs7792298 | 7 | PTN intron | Gen | 0.047 | SBP | Comp_BA | 5.50 | 0.99 | −7.18 | 1.29 | 2.90E-08 | 2.08E-08 |
| rs11086907 | 20 | TOX2 intron | Gen | 0.102 | DBP | Comp_HS+ | 4.12 | 0.81 | −4.81 | 0.87 | 3.74E-08 | 2.61E-07 |
Bolded values are those with P < 5.00E-08.
Abbreviations: Comp_BA, dichotomous variable distinguishing those without a bachelor’s degree from those with a bachelor’s degree; Comp_HS+, dichotomous variable distinguishing those with no more than high school education from those with at least some college; DBP, diastolic blood pressure; df, degrees of freedom; Gen, genotyped; Int, interaction effect; Imp, imputed; MAF, minor allele frequency; Main, main effect; SBP, systolic blood pressure; SNP, single nucleotide polymorphism.