Table 3.
Ultrastructural Analysis of Neuromuscular Junctions (Mean ± SEM)
Immunization | Junctional segments per muscle fiber length (um) (n) | Endplate Index* (n) | Secondary clefts per primary cleft length (um) (n) | Nerve Terminal Area (um2) (n) |
---|---|---|---|---|
Adjuvant Control | 0.15±0.013 (18) | 5.80±0.49 (23) | 2.08±0.18 (23) | 0.064±0.011 (23) |
MuSK | 0.25±0.002 (15) P<0.0001 |
1.67±0.11 (43) P<0.0001 |
0.37±0.001 (43) P<0.0001 |
7.74±0.52 (43) P<0.0001 |
Length of post-synaptic membrane/length of apposed pre-synaptic membrane