Table 1.
Acoustic startle response (ASR) of Wistar rats (WRs) and spontaneously hypertensive rats (SHRs) treated with vehicle (VEH), 0.3, 1, or 3 mg/kg WIN55212,2 (WIN – Experiment 1); VEH, 0.75, 1.5, or 3 mg/kg rimonabant (RIMO – Experiment 2); VEH, 1, 5, or 10 mg/kg AM404 (AM – Experiment 3); VEH, 15, 30, or 60 mg/kg cannabidiol (CBD – Experiment 4).
| Experiment 1 | VEH | WIN 0.3 | WIN 1 | WIN 3 |
|---|---|---|---|---|
| WRs | 464.6 ± 107.3 (n = 10) | 422.3 ± 161.4 (n = 10) | 588.3 ± 151.4 (n = 10) | 588 ± 176.9 (n = 10) |
| SHRs | 87.8 ± 10.7* (n = 10) | 82.3 ± 10.7* (n = 10) | 87.6 ± 15.1* (n = 10) | 82.5 ± 27.3* (n = 10) |
| Experiment 2 | VEH | RIMO 0.75 | RIMO 1.5 | RIMO 3 |
| WRs | 491.2 ± 109.3 (n = 11) | 477.3 ± 138.8 (n = 11) | 534.4 ± 144.1 (n = 11) | 158.6 ± 76.3 (n = 11) |
| SHRs | 198.7 ± 115.1* (n = 9) | 71.1 ± 9.4* (n = 10) | 140.5 ± 31.1* (n = 11) | 85.2 ± 8.6* (n = 10) |
| Experiment 3 | VEH | AM 1 | AM 5 | AM 10 |
| WRs | 478.0 ± 136.3 (n = 10) | 539.6 ± 157.0 (n = 9) | 613.2 ± 126.9 (n = 10) | 450.7 ± 125.8 (n = 10) |
| SHRs | 127.2 ± 13.8* (n = 10) | 135.3 ± 27.9* (n = 11) | 76.0 ± 10.6* (n = 10) | 100.0 ± 23.2* (n = 10) |
| Experiment 4 | VEH | CBD 15 | CBD 30 | CBD 60 |
| WRs | 486.2 ± 188.3 (n = 10) | 239.6 ± 98.2 (n = 9) | 234.3 ± 56.6 (n = 10) | 343.7 ± 72.3 (n = 10) |
| SHRs | 92.5 ± 8.2* (n = 10) | 76.1 ± 8.5* (n = 10) | 117.4 ± 13.6* (n = 10) | 57.1 ± 6.9* (n = 10) |
*p < 0.001 compared to WRs. Two-way ANOVA. Data are reported as mean ± SE.