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Btk−/− mice with impaired CD11ahiFcγRIIIhi B cell generation are more susceptible to LM infection. WT and Btk−/− mice were infected with LM. CFUs in the spleen (A) and liver (B) and serum IFN-γ (C) were analyzed at the indicated time. (D) The CD11ahiFcγRIIIhi cell proportion in splenic B cells was determined in WT and Btk−/− mice on day 3 post-LM infection. Data shown represent the mean ± SD of triplicate experiments. *P < 0.05, **P < 0.01.
