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. 2013 Dec 3;24(2):204–217. doi: 10.1038/cr.2013.158

Figure 5.

Figure 5

Ectopic expression of MPZL1 leads to increased phosphorylation of multiple pro-metastatic proteins. (A) The overexpression of MPZL1 in HUH-7 and Hep3B cells increases the phosphorylation of FAK (Y397) and Src (Y416) proteins. (B) The knockdown of MPZL1 in SK-HEP-1 cells decreases the phosphorylation of FAK (Y397) and Src (Y416) proteins. (C) The overexpression of MPZL1 in HUH-7 and Hep3B cells leads to the increased phosphorylation of cortactin (Y421) protein. (D) The knockdown of MPZL1 in SK-HEP-1 cells decreases the phosphorylation of cortactin (Y421) protein. (E) The overexpression of MPZL1 in HUH-7 cells results in the increased phosphorylation of SHP-2 (Y580) protein. (F) Targeted knockdown of the SHP-2 gene using siRNAs attenuates the increased phosphorylation of Src (Y416) and cortactin (Y421) caused by the overexpression of MPZL1 in HUH-7 cells.