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. Author manuscript; available in PMC: 2014 Feb 6.
Published in final edited form as: ACS Nano. 2013 Jun 7;7(6):5350–5359. doi: 10.1021/nn401199k

Figure 3.

Figure 3

Effect of 6-mercapto-1-hexanol (MCH) self-assembled monolayer (SAM) for aptamer–TVP binding. TVP molecules are bound on the aptamer-functionalized substrate (a) with and (b) without a monolayer of MCH. Due to the backfilling of MCH molecules, binding efficiency of aptamers is improved, and nonspecific adsorption of analyte is minimized. This effect is verified by experimental results shown in (c) and (d). The experiments were performed with 10 nM TVP samples on different substrates: aptamers with MCH layer (green), aptamers without MCH layer (red), and MCH only (blue).