Fig. 2.

The induction of carcinogenesis through imbalance in apoptosis and cell cycle regulation. (A) Under disease free condition tissue homeostasis is achieved through a balance between cell proliferation and apoptosis. (B) Dysregulation in cell cycle process leads to increased activation or decreased inhibition resulting in uncontrolled proliferation. (C) The loss of proapoptotic and gain of anti-apoptotic regulators result in increased cell survival and cell number. These events are implicated during the complete imbalance in tissue homeostasis leading to the formation of carcinoma.