Table 1.
Characteristics of included studies
| Author | Year | Country | Ethnicity | Source | Genotyping method | Cancer type |
Total number |
Cases |
Controls |
HWE of controls |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | Lys/Lys | Lys/Gln | Gln/Gln | Lys/Lys | Lys/Gln | Gln/Gln | ||||||||
| Sturgis [26] |
2000 |
America |
Caucasian |
HB |
PCR-RFLP |
SCCHN |
189 |
496 |
75 |
83 |
31 |
218 |
221 |
57 |
0.9304 |
| Gajecka [21] |
2005 |
Poland |
Caucasian |
HB |
PCR-RFLP |
LC |
293 |
320 |
110 |
135 |
48 |
87 |
175 |
58 |
0.0659 |
| Huang [23] |
2005 |
America |
Caucasian |
Mix* |
TaqMan-PCR |
HNC |
425 |
683 |
176 |
188 |
61 |
296 |
292 |
95 |
0.0951 |
| Rydzanicz [24] |
2005 |
Poland |
Caucasian |
HB |
PCR-RFLP |
HNC |
172 |
143 |
69 |
73 |
30 |
54 |
64 |
25 |
0.4265 |
| Kietthubthew [32] |
2006 |
Thailand |
Asian |
PB |
PCR-RFLP |
SCCOC |
105 |
164 |
83 |
21 |
1 |
126 |
36 |
2 |
0.7489 |
| Matullo [25] |
2006 |
Europe |
Caucasian |
nest |
TaqMan-PCR |
UADC |
82 |
1094 |
34 |
39 |
9 |
397 |
504 |
193 |
0.1330 |
| Ramachandran [37] |
2006 |
India |
Asian |
HB |
PCR-RFLP |
OC |
110 |
110 |
49 |
46 |
15 |
71 |
31 |
8 |
0.0908 |
| An [22] |
2007 |
America |
Caucasian |
HB |
PCR-RFLP |
SCCHN |
829 |
854 |
330 |
394 |
105 |
358 |
386 |
110 |
0.7091 |
| Bau [27] |
2007 |
Taiwan |
Asian |
HB |
PCR-RFLP |
OC |
154 |
105 |
134 |
18 |
2 |
89 |
15 |
1 |
0.6824 |
| Yang [29] |
2007 |
China |
Asian |
PB |
PCR-RFLP |
NPC |
153 |
168 |
128 |
24 |
1 |
124 |
43 |
1 |
0.1805 |
| Majumder [31] |
2007 |
India |
Asian |
HB |
PCR-RFLP |
OC |
309 |
388 |
158 |
125 |
26 |
190 |
158 |
40 |
0.4030 |
| Harth [35] |
2008 |
Germany |
Caucasian |
HB |
PCR-RFLP |
SCCHN |
312 |
300 |
111 |
154 |
47 |
108 |
149 |
43 |
0.4642 |
| Mitra [34] |
2009 |
North India |
Caucasian |
HB |
PCR-RFLP |
SCCHN |
275 |
385 |
88 |
148 |
39 |
163 |
179 |
43 |
0.5571 |
| Jelonek [33] |
2010 |
Poland |
Caucasian |
HB |
PCR-RFLP |
HNC |
103 |
110 |
29 |
52 |
22 |
38 |
60 |
12 |
0.1030 |
| Ji [28] |
2010 |
Korea |
Asian |
HB |
PCR-SBE |
SCCHN |
267 |
348 |
232 |
32 |
3 |
298 |
48 |
2 |
0.9645 |
| Stembalska [38] |
2011 |
Poland |
Caucasian |
HB |
PCR-RFLP |
LSCC |
60 |
100 |
20 |
26 |
14 |
32 |
46 |
22 |
0.4795 |
| Kumar [36] |
2012 |
North India |
Caucasian |
HB |
PCR-RFLP |
SCCHN |
278 |
278 |
92 |
125 |
61 |
129 |
110 |
39 |
0.0531 |
| Yuan [30] | 2012 | China | Asian | PB | TaqMan-PCR | HNC | 394 | 887 | 333 | 57 | 4 | 752 | 129 | 6 | 0.8556 |
HB hospital-based study, PB population-based study, *two population-based studies and one hospital-based study, nest nested case–control study, PCR-RFLP polymerase chain reaction-restriction fragment length polymorphism, PCR-SBE polymerase chain reaction-single base extension, HNC head and neck cancer, SCCHN squamous cell cancer of the head and neck, NPC nasopharyngeal cancer, LC laryngeal cancer, LSCC laryngeal squamous cell cancer, UADC upper aerodigestive tract cancer, OC oral cance, HWE Hardy–Weinberg equilibrium.