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. 2014 Jan 27;15:28. doi: 10.1186/1471-2105-15-28

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Copyright © 2014 Cole et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Distribution of functional sites from UniProtKB/Swiss-Prot that affected by nsSNVs. A) Distribution of loss of functional sites caused by nsSNVs from cases. B) Distribution of loss of functional sites caused by nsSNVs from controls. C) Heatmap representation of the overlap of nsSNVs in cases and control (nsSNVs found in both cases and controls are marked green and marked red if they are unique to case or control. All protein accessions and corresponding position were given a numerical ID (Additional file 1: Table S1) to facilitate visualization of the vertical axis in the heatmap.