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. 2013 Nov 19;18(1):156–169. doi: 10.1111/jcmm.12178

Figure 1.

Figure 1

Myofibroblasts in bleomycin-damaged lung could be derived from bone marrow derived-mesenchymal stem cells. (A) Immunofluorescence staining for EGFP (green), Sca-1 (red), and CD44 (purple) in the lung of Saline- (upper) or BLM-(lower) challenged mice with EGFP bone marrow replacement. DAPI (blue) staining shows the nucleus. EGFP/Sca-1/CD44 co-positive cells are indicated with arrows. (B) Immunofluorescence staining for Sca-1 (blue), CD44 (purple), and α-SMA (red) in the lung of Saline- (upper) or BLM-(lower) challenged mice with EGFP bone marrow replacement. EGFP/Sca-1/CD44/α-SMA co-positive cells are indicated with arrows. (C) Quantification of total EGFP-positive cells in the lung of Saline and BLM groups with EGFP transgenic bone marrow replacement. (D) Proportion of EGFP/Sca-1/CD44 co-positive cells in the lung of Saline and BLM groups with EGFP transgenic bone marrow replacement. (E) Proportion of EGFP/α-SMA co-positive cells in the lung of Saline and BLM groups with EGFP transgenic bone marrow replacement. (F) Proportion of EGFP/CD44/Sca-1/α-SMA co-positive cells in the lung of Saline and BLM groups with EGFP transgenic bone marrow replacement. Each value represents the mean ± SE. n = 6 mice in each group. **P < 0.01. BLM: bleomycin.