Table 1.

Mutation frequency of PIK3CA in major human cancers.

Cancer type	Mutation frequency	References
Brain	5–20%	(Samuels et al., 2004, Hartmann et al., 2005)
Breast	21–28%	(Bachman et al., 2004, Saal et al., 2005)
Cervix	36%	(Janku et al., 2011)
Colorectal	30%	(Samuels et al., 2004)
Endometrium	23%	(Garcia-Dios et al., 2013)
Esophagus	6–11%	(Dulak et al., 2013, Phillips et al., 2006)
Gastric	9–25%	(Li et al., 2005, Samuels et al., 2004)
Liver	28–35%	(Lee et al., 2005, Colombino et al., 2012)
Lung	5%	(Yamamoto et al., 2008)
Ovary	25%	(Levine et al., 2005)
Pancreas	11%	(Schonleben et al., 2006)
Thyroid	11%	(Garcia-Rostan et al., 2005)