Immunostaining for aquaporin-1 (AQP1) on tissue microarray (TMA). (A) The normal mucosal epithelium exhibited no AQP1 staining, (B) score 0, (C) score 2 (intensity 1, distribution 1) and (D) score 4 (intensity 2, distribution 2). The AQP1 score was (A) 0 in 64 patients (53.3%), (B) 2 in 13 patients (10.8%), (C) 3 in 17 patients (14.2%) and (D) 4 in 26 patients (21.7%).