Table III.
Diagnostic immunomarkers for leiomyosarcoma, STUMP and leiomyoma variants.
| Genes | Leiomyosarcoma | STUMP | Leiomyoma variants
|
Usual leiomyoma | |
|---|---|---|---|---|---|
| Bizarre | Cellular | ||||
| p16 | 2+ diffuse | 1+ | 1+ to 2+ | 1+ | 0 to 1+ focal |
| p21 | 2+ | 1+ | 1+ to 2+ | 1+ | 0 to 1+ |
| p53 | 2+ | 1+ | 1+ to 2+ | 0 | 0 |
| Ki-67 | 1+ | 1+ | 0 to 1+ | 0 | 0 |
Immunohistochemical staining techniques were applied to evaluate the frequencies of p16, p21, p53 and Ki-67 expression. 0, absent; 1+, positive; 2+, strongly positive. STUMP, smooth muscle tumor of uncertain malignant potential.