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Tumor volume doubling time (TVDT) according to histological grade of differentiation of hepatocellular carcinoma. The mean ± standard deviation TVDT for Edmondson grade 1 (Ed1), Ed2 and Ed3 was 138.3±110.3, 94.9±91.5 and 32.2±20.8 days, respectively. The TVDT was significantly longer for Ed1 and Ed2 compared to that for Ed3 (*P<0.05).
