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Serum α-fetoprotein doubling time (T2AFP) according to histological grade of differentiation of hepatocellular carcinoma. The mean ± standard deviation T2AFP for Edmondson grade 2 (Ed2) and Ed3 was 121.0±167.5 and 37.3±24.6 days, respectively. There was a statistically significant difference in T2AFP between Ed2 and Ed3 (*P<0.01).
