Figure 10. Effects of COX2 inhibition on model simulated [PGE2] in wild type MEF cells at 48 hours post radiation.

Experimentally, COX2 inhibition can be achieved through treatment of cells with exogenous competitive inhibitors. In this study, the competitive inhibition was modeled through introducing a parameter, α, which was the ratio of inhibitor concentration versus equilibrium constant of binding between COX2 and its inhibitor. It can be observed that [PGE2] decreased rapidly with increasing the value of α.