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. 2014 Feb 6;10(2):e1003471. doi: 10.1371/journal.pcbi.1003471

Figure 3. Modeling suggests Hsp72 attenuation of IKK is essential for differential IKK and NF-κB activation.

Figure 3

A. Model simulations show expected dynamics of IKK, NF-κB and total IκBα protein when Hsp72 inhibits TNF-induced IKK activation. Each curve corresponds to simulations with rate ka multiplied by the factor indicated. B. Model simulations when Hsp72 is assumed to inhibit phosphorylation of IκBα (rate kc2a). When phosphorylation is sufficiently attenuated, peak NF-κB activation drops similar to levels observed experimentally, but IKK activation at early times is largely unaffected.