Skip to main content
. 2014 Feb 6;10(2):e1003471. doi: 10.1371/journal.pcbi.1003471

Figure 7. Updated mechanistic diagram for Hsp72 regulation of NF-κB signaling in microglia.

Figure 7

Hsp72 regulation at the upstream level inhibiting IKK is an essential component in microglia, although the precise biomolecular mechanism cannot be discriminated. Hsp72 also plays a critical role in reducing synthesis of the p65 NF-κB subunit. Additionally, Hsp72 appears to increase the induction of IκBα transcript. Downstream of IKK, Hsp72 regulation may act to decrease phosphorylation and/or other steps in the stimulus-induced degradation of IκBα, though it appears less essential than the other two levels of regulation in this particular cell type and context.