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Activation of RhoA/Rho-kinase pathway in mesenteric PVAT. A, Mesenteric PVAT from MetS mice showed increased gene expression of RhoA and Rho-kinases. Rho-kinase activity was also significantly increased, which was not seen in I-MetS mice (B). Data represent the mean ± SEM from 2–4 independent experiments, n = 3–4 mice/group, *P < 0.05, **P < 0.01.
