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. 2014 Jan 30;7:8. doi: 10.1186/1755-8794-7-8

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Copyright © 2014 Koestler et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Identification of epigenetically mediated genetic risk factors for EOC. (A) Directed acyclic graphs (DAGs) depicting the possible relationships between a causal factor (G), a potential mediator (M), and an outcome (Y). Top, DAG for the methylation-mediated relationship, wherein G acts on Y through M. Middle, DAG for the methylation-consequential (reverse causality) relationship, in which changes in M arise as a consequence of Y. Bottom, DAG for the methylation-independent relationship, wherein G acts on M and Y independently. (B) The four components of the CIT. (C) Flow diagram illustrating the various filtering steps, and ensuing results, used to identify methylation sites that are candidates for mediators of genetic risk for EOC.