Table 3. Genes up-regulated in stationary phase in Cultures 1 and 2 and in further conditions in vitro or in vivo.
Gene ID (Rv no.) | Gene Name | Clusterno. | Function | Also up-regulated in the following studies: |
Rv0083 | 2 | Oxidoreductase | Human granuloma v in vitro culture in 7H9; [27] | |
Rv0122 | 2 | Hypothetical protein | 96h starvation in PBS [23] | |
Rv0251c | hsp | 16 | Heat shock protein | Human granuloma v in vitro [27] 96h starvation in PBS [23] 75 days starvation [10] |
Rv0284 | 50 | Conserved membrane protein | 75 days starvation [10] | |
Rv1072 | 11 | Conserved membrane protein | 75 days starvation [10] | |
Rv1285 | cysD | 2 | Sulfate adenylyltransferase | 75 days starvation [10] |
Rv1461 | 15 | Conserved hypothetical protein | 75 days starvation [10] | |
Rv1462 | 3 | Conserved hypothetical protein | 75 days starvation [10] | |
Rv2497c | pdhA | 2 | Pyruvate dehydrogenase | 75 days starvation [10] |
Rv2642 | 14 | Transcriptional regulator, arsR | Human granuloma v in vitro culture in 7H9 [27] | |
Rv2710 | sigB | 16 | RNA polymerase sigma factor | 75 days starvation [10] |
Rv3139 | fadE24 | 3 | Acyl-CoA dehydrogenase | 75 days starvation [10] |
Rv3173c | 4 | Transcriptional regulator, tetR acrR-family | 75 days starvation [10] | |
Rv3555c | 3 | Conserved hypothetical protein | Human granuloma v in vitro culture in 7H9, Human granuloma v pericavity [27] |
Table 3 Genes that were up-regulated at 48 h in macrophages [26] and in Cultures 1 and 2 of M. tuberculosis in late stationary phase (Table S3, supporting information), and in at least one other condition either in vitro or in vivo model as indicated in Table 3. The details of cluster profiles can be found in the supporting information at http://xenakis.mrc-bsu.cam.ac.uk/wernisch/enrichment/html/.