Table 4. Grade 3 and/or grade 4 adverse effects observed according to CTCAE version 4.0.
| PF+ cetuximab | Cisplatin +5FU+cetuximab | Carbooplatin +5FU+cetuximab | Cetuximab | |||||
| No. | % | No. | % | No. | % | No. | % | |
| Febrile | 6 | 5.7 | 4 | 6.8 | 2 | 4.3 | 1 | 0.9 |
| Neutropenia | 5 | 4.7 | 4 | 6.8 | 1 | 2.2 | 0 | - |
| Skin rash | 4 | 3.8 | 0 | - | 4 | 8.7 | 7 | 6.4 |
| Mucositis | 4 | 3.8 | 1 | 1.7 | 3 | 6.5 | 1 | 0.9 |
| Anemia | 3 | 2.8 | 0 | - | 3 | 3.5 | 0 | - |
| Hypomagnesemia | 3 | 2.8 | 2 | 3.4 | 1 | 2.2 | 0 | - |
| Pneumonia | 3 | 2.8 | 1 | 1.7 | 2 | 4.3 | 0 | - |
| Dispneia | 0 | - | 0 | - | 0 | - | 1 | 0.9 |
| Sepsis | 1 | 0.9 | 1 | 1.7 | 0 | - | 0 | - |
| Infusion reactions | 1 | 0.9 | 1 | 1.7 | 0 | - | 0 | - |
| Vomiting | 1 | 0.9 | 1 | 1.7 | 0 | - | 0 | - |
| Low platelet count | 1 | 0.9 | 1 | 1.7 | 0 | - | 0 | - |
Abbreviations: CTCAE, Common Terminology Criteria for Adverse Events. 5FU, 5-fluourouracil.