Table 3. List of the up- and down-regulated genes of the gene expression signature of 44 probes.
| Colorectal Adenoma vs. Normal | Colorectal Cancer vs. Normal | Colorectal Cancer vs. Colorectal Adenoma | ||||||||
| Gene Symbol | Probe Name | P-value | Fold-Change | Regulation | P-value | Fold-Change | Regulation | P-value | Fold-Change | Regulation |
| SCARA5 | A_23_P94103 | 1.04E-14 | 11.54 | down | 1.11E-03 | 36.56 | down | 1.27E-03 | 3.17 | down |
| IGHA2 | A_23_P61042 | 7.04E-03 | 3.77 | down | 3.43E-03 | 21.85 | down | 7.54E-03 | 5.80 | down |
| BEST2 | A_23_P16225 | 4.59E-03 | 4.25 | down | 1.11E-03 | 20.25 | down | 9.80E-03 | 4.76 | down |
| C6orf105 | A_23_P156826 | 3.72E-03 | 2.78 | down | 1.86E-03 | 18.54 | down | 9.22E-05 | 6.66 | down |
| FAM55D | A_23_P320216 | 1.00E-02 | 2.25 | down | 3.65E-03 | 17.45 | down | 2.00E-05 | 7.76 | down |
| DNASE1L3 | A_23_P257993 | 2.08E-04 | 2.39 | down | 1.94E-03 | 12.77 | down | 8.39E-06 | 5.34 | down |
| UGT1A6 | A_23_P60599 | 2.65E-03 | 2.33 | down | 3.46E-03 | 10.89 | down | 1.43E-04 | 4.67 | down |
| LRRC19 | A_23_P364625 | 1.38E-07 | 3.55 | down | 6.01E-03 | 9.42 | down | 3.52E-03 | 2.65 | down |
| IGJ | A_23_P167168 | 5.24E-03 | 2.50 | down | 3.42E-03 | 8.87 | down | 2.42E-03 | 3.55 | down |
| ISX | A_32_P217140 | 3.53E-04 | 2.65 | down | 4.80E-03 | 8.32 | down | 2.19E-03 | 3.14 | down |
| NR3C2 | A_23_P392470 | 3.98E-06 | 2.58 | down | 6.39E-03 | 7.53 | down | 3.79E-04 | 2.92 | down |
| SMPDL3A | A_23_P72117 | 1.20E-06 | 3.08 | down | 1.90E-03 | 7.07 | down | 2.30E-03 | 2.29 | down |
| HSD11B2 | A_23_P14986 | 2.52E-06 | 2.64 | down | 1.16E-03 | 7.07 | down | 6.38E-05 | 2.68 | down |
| RDH5 | A_24_P218814 | 2.54E-03 | 2.22 | down | 8.51E-04 | 6.34 | down | 7.18E-04 | 2.85 | down |
| SEPP1 | A_23_P121926 | 3.11E-06 | 2.95 | down | 2.45E-03 | 6.27 | down | 6.02E-03 | 2.13 | down |
| ITM2C | A_24_P379820 | 3.47E-03 | 2.04 | down | 2.84E-03 | 5.85 | down | 1.14E-03 | 2.87 | down |
| ITM2C | A_24_P402690 | 5.68E-04 | 2.08 | down | 5.51E-03 | 5.62 | down | 3.14E-04 | 2.70 | down |
| PBLD | A_23_P149998 | 3.95E-05 | 2.35 | down | 9.07E-03 | 5.58 | down | 5.90E-03 | 2.38 | down |
| PBLD | A_24_P112395 | 1.11E-04 | 2.21 | down | 7.65E-03 | 5.31 | down | 3.69E-03 | 2.40 | down |
| LOC400573 | A_32_P515920 | 7.71E-06 | 2.50 | down | 1.24E-03 | 5.17 | down | 3.48E-03 | 2.06 | down |
| ASAP3 | A_23_P114689 | 5.04E-05 | 2.37 | down | 7.64E-04 | 5.03 | down | 2.44E-03 | 2.13 | down |
| C1orf115 | A_23_P160433 | 1.89E-04 | 2.23 | down | 4.35E-03 | 4.83 | down | 2.85E-03 | 2.16 | down |
| C1orf115 | A_24_P131173 | 8.42E-04 | 2.08 | down | 6.01E-03 | 4.46 | down | 3.10E-03 | 2.15 | down |
| DPT | A_23_P200741 | 6.20E-18 | 27.31 | down | 6.92E-03 | 5.36 | down | 3.56E-07 | 5.09 | up |
| SLIT3 | A_23_P58588 | 3.42E-14 | 12.05 | down | 8.11E-04 | 5.19 | down | 2.55E-03 | 2.32 | up |
| CFHR3 | A_23_P103256 | 8.67E-16 | 9.06 | down | 5.95E-03 | 4.02 | down | 3.63E-04 | 2.25 | up |
| CFH | A_23_P200160 | 3.65E-11 | 8.65 | down | 3.43E-03 | 3.90 | down | 6.86E-03 | 2.22 | up |
| FBLN1 | A_23_P433016 | 8.05E-13 | 12.99 | down | 5.53E-03 | 3.40 | down | 9.13E-05 | 3.82 | up |
| CCDC80 | A_23_P58082 | 7.18E-14 | 15.11 | down | 5.62E-03 | 3.35 | down | 5.61E-06 | 4.52 | up |
| FBLN1 | A_23_P211631 | 1.36E-11 | 13.36 | down | 7.13E-03 | 3.20 | down | 1.02E-04 | 4.18 | up |
| SPARCL1 | A_23_P113351 | 2.28E-11 | 6.11 | down | 6.48E-03 | 3.01 | down | 4.95E-03 | 2.03 | up |
| CRYAB | A_24_P206776 | 2.31E-15 | 5.69 | down | 2.93E-03 | 2.72 | down | 1.96E-04 | 2.09 | up |
| VSIG4 | A_23_P217269 | 3.01E-10 | 8.43 | down | 2.61E-03 | 2.65 | down | 3.99E-04 | 3.18 | up |
| PLN | A_23_P30614 | 2.07E-07 | 8.08 | down | 3.37E-03 | 2.61 | down | 6.24E-03 | 3.10 | up |
| ITIH5 | A_23_P411993 | 3.16E-12 | 5.07 | down | 6.28E-03 | 2.40 | down | 2.69E-04 | 2.11 | up |
| DACT3 | A_23_P360964 | 3.82E-12 | 6.29 | down | 9.46E-03 | 2.30 | down | 1.11E-04 | 2.73 | up |
| INHBA | A_23_P122924 | 1.66E-06 | 5.72 | up | 6.54E-04 | 41.06 | up | 1.22E-05 | 7.18 | up |
| TRIB3 | A_23_P210690 | 1.73E-04 | 3.17 | up | 1.45E-03 | 9.88 | up | 3.10E-03 | 3.11 | up |
| JUB | A_23_P54055 | 2.03E-08 | 4.24 | up | 1.11E-03 | 8.77 | up | 2.75E-03 | 2.07 | up |
| PSAT1 | A_23_P259692 | 4.48E-03 | 2.47 | up | 5.72E-03 | 6.95 | up | 1.47E-03 | 2.81 | up |
| MYBL2 | A_23_P143190 | 3.96E-05 | 2.40 | up | 8.37E-03 | 5.19 | up | 2.58E-03 | 2.16 | up |
| SKA3 | A_23_P340909 | 1.05E-04 | 2.15 | up | 1.86E-03 | 4.65 | up | 3.87E-04 | 2.16 | up |
| UBE2S | A_32_P184933 | 2.74E-05 | 2.01 | up | 1.70E-03 | 4.56 | up | 4.22E-05 | 2.27 | up |
| TIMP1 | A_23_P62115 | 3.34E-04 | 2.11 | up | 2.25E-03 | 4.39 | up | 4.62E-03 | 2.08 | up |
Signature of 44 probes corresponding to genes showing alterations in the three comparisons (CRA vs. NOR, CRC vs. CRA and CRC vs. NOR; ≥2.0 FC, P-value ≤0.01 by t-test with FDR).