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. 2014 Feb 6;9(2):e87893. doi: 10.1371/journal.pone.0087893

Table 1. Tumorigenic Potential of MSC-lung Carcinoma Hybrids.

Tumor incidence/number of injections
Number of cells injected A549 A549/MSC H460 H460/MSC SK-MES-1 SK-MES-1/MSC
1×106 8/10 10/10 9/10 10/10 8/10 10/10
1×105 3/10 9/10* 3/10 8/10* 4/10 8/10*
1×104 0/10 5/10* 0/10 4/10* 0/10 6/10*
1×103 0/10 2/10* 0/10 2/10* 0/10 3/10*

Note: Data are given as number/total (percentage). Control MSCs implanted alone into 10 mice (inoculum, 1×106 cells/mouse) were nontumorigenic.

*Statistically significant difference by two-sided Fisher’s exact test with respect to the rate of tumor incidence by parental lung cancer cells (P<0.001).