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. 2014 Feb 6;9(2):e88193. doi: 10.1371/journal.pone.0088193

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© 2014 Federici et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A: Intracellular CisPt level in more drug-resistant (Me30966) and less drug-resistant (MCF7) cells at different pH (5.0, 6.0 and 7.4) of culture medium. Significance (p<0.05) refers to CisPt level at pH 5.0 compared to pH 7.4. B: Intracellular CisPt level in Me30966 cells in function of different incubation times (24, 48, 72 hours) in UNB condition before drug administration. Significance (p<0.05) refers to CisPt uptake after 72 hours compared to 24 hours. Representative of three independent experiments are reported.