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. 2014 Feb 6;9(2):e88193. doi: 10.1371/journal.pone.0088193

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© 2014 Federici et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A: Effect of PPI on CisPt uptake in Me30966 cells in function of different pH (UNB, 6.0 and 5.0) culture medium. CTR: Me30966 cells incubated with CisPt, without PPI pre-treatment; CTR+PPI: Me30966 cells pretreated with PPI and then incubated with CisPt. Significance (p<0.05) refers to CisPt cellular uptake at 5.0 and 6.0 pH in comparing PPI pretreatment to CTR in UNB medium. B: Effect of PPI on drug release at different pH (UNB, 6.0 and 5.0). CisPt ng/l present in cell culture medium obtained from cells pretreated with PPI and then incubated with CisPt. p<0.05. Representative of three independent experiments are reported.