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. 2014 Feb 6;9(2):e88193. doi: 10.1371/journal.pone.0088193

Figure 4. HPLC-Q-ICP-MS chromatograms of a standard solution of CisPt.

Figure 4

Chromatogram of CisPt solution dissolved in NaCl 0.9% (A) and in water after sonication (30 min) at 80°C (90 min) (B). Chromatograms of CisPt dissolved in cell culture medium after dissolution (C) and after 6 hours incubation (D), peak of native form of Cis-Pt at 5.2 min; peak of monohydrated CisPt at 11.3 min. Chromatogram of Me30966 cells lysate solution containing native and monohydrated forms of CisPt (E); chromatogram of exosomes lysate solution containing only the native form of the drug (F). Representative of three independent experiments are reported.