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Plot of PSA versus LogP for candidate compounds showing the 95% and 99% confidence limit ellipses corresponding to the blood–brain barrier and intestinal absorption models.
Abbreviations: ADMET, absorption, distribution, metabolism, excretion, and toxicity properties of a molecule within an organism; AlogP, the logarithm of the partition coefficient between n-octanol and water; BBB, blood–brain barrier; PSA, polar surface area.
