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Kinetic parameters for debrisoquine hydroxylation activity in hepatic microsomes prepared from Tg-CYP2D6 mice (n = 4, mean ± S.D.)
Vmax, maximum velocity; Km, Michaelis-Menten constant.
| Parameter | Virgin | G7 | G14 | G21 | PP7 |
|---|---|---|---|---|---|
| Vmax (pmol/min/mg protein) | 749 ± 125 | 1130 ± 420 | 1240 ± 160a | 2120 ± 60b | 1080 ± 200 |
| Km (μm) | 210 ± 77 | 291 ± 54 | 296 ± 87 | 278 ± 26 | 285 ± 19 |
a p < 0.05.
b p < 0.01 versus virgin.
