FIGURE 5.

The role of SENP2 and myostatin in a cachexia mouse model. A, 8-week-old C57BL/6 mice were injected with PBS or Lewis lung carcinoma cells. The skeletal muscle morphology and body weight of PBS- or LLC-injected mice were measured 6 weeks after injection. mRNA levels of Senp2 (B) and myostatin (C) in skeletal muscle were measured by real-time PCR. The data are presented as mean ± S.D. of three independent experiments. Differences between LLC- and PBS-injected mice were significant (p < 0.05, Student's t test).