FIGURE 9.

Proposed model. GPI-GnT complex includes different subunits. However, the interactions between the subunits are not known. Our model proposes that GPI2 and GPI19 subunits of GPI-GnT complex are negatively co-regulated. Thus, whereas GPI19 seems to directly affect ERG11 levels, and thereby alter azole response of C. albicans, GPI2 primarily affects Ras signaling and thus affects hyphal morphogenesis in C. albicans. The effect of GPI2 disruption on ERG11 appears to be via its interaction with GPI19, whereas the effect of GPI19 on Ras1 activity is dependent on its interaction with GPI2.