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. 2014 Jan 31;7:57–67. doi: 10.2147/IJNRD.S37887

Figure 1.

Figure 1

Mitochondrial genome with the positions of mutations associated with a kidney phenotype. A schematic of the circular 16,569 base pair human mitochondrial genome is shown with the position of 13 protein-coding mitochondrial genes (ND1, ND2, CO1, CO2, ATP8, ATP6, CO3, ND3, ND4L, ND4, ND5, ND6, CYTB), two ribosomal ribonucleic acid (RNA) molecules (RNR1, RNR2) and the noncoding D-loop, depicted as labeled boxes on the interior of the circle. The position of the 22 mitochondrial transfer RNAs (tRNAs) is shown with the solid-gray boxes with the single-letter amino acid designation shown for the respective tRNA. The position of the mitochondrial transfer deoxyribonucleic acid (mtDNA) single-base mutations are shown with a solid-bold line on the interior of the circle connected to a light line indicating the base position of the mutation. Large mitochondrial DNA deletions are represented by bold lines labeled 1–8 on the exterior of the circle phenotype.