Table I. Novel FE65 interacting protein candidates (significant candidates) (corresponding table in color can be found in supplemental Table S1).
| Accession | Protein name | Mean counts, FE65 eluate | Mean counts, control eluate | Ratio | t test |
|---|---|---|---|---|---|
| Q9P2U7a | Vesicular glutamate transporter 1 (SLC17A7, VGLUT1) | 43.8 | 3.9 | 11.2 | 0.0001 |
| P50993b | Sodium/potassium-transporting ATPase subunit α-2 (ATP1A2) | 86.2 | 30.2 | 2.9 | 0.0002 |
| O00213 | Amyloid β A4 precursor protein-binding family B member 1 (FE65) | 3629.5 | 714.4 | 5.1 | 0.0003 |
| Q7L0J3b | Synaptic vesicle glycoprotein 2A (SV2A) | 21.4 | 5.9 | 3.6 | 0.0008 |
| P34932 | Heat shock 70 kDa protein 4 (HSPA4) | 47.6 | 7.5 | 6.4 | 0.0018 |
| P23634b | Plasma membrane calcium-transporting ATPase 4 (ATP2B4) | 6.2 | 0.9 | 7.1 | 0.0032 |
| P20020b | Plasma membrane calcium-transporting ATPase 1 (ATP2B1) | 12.8 | 5.4 | 2.4 | 0.0039 |
| P78559b | Microtubule-associated protein 1A (MAP1A) | 6.7 | 1.8 | 3.7 | 0.0065 |
| P43003b | Excitatory amino acid transporter 1 (SLC1A3) | 22.0 | 12.1 | 1.8 | 0.0072 |
| P00505 | Aspartate aminotransferase, mitochondrial (GOT2) | 3.8 | 0.3 | 14.7 | 0.0094 |
| P07954b | Fumarate hydratase, mitochondrial (FH) | 21.4 | 11.7 | 1.8 | 0.0101 |
| P08195 | 4F2 cell-surface antigen heavy chain (SLC3A2) | 12.3 | 3.2 | 3.8 | 0.0102 |
| P32004b | Neural cell adhesion molecule L1 (L1CAM) | 6.8 | 2.0 | 3.4 | 0.0120 |
| P14415 | Sodium/potassium-transporting ATPase subunit β-2 (ATP1B2) | 7.5 | 1.7 | 4.3 | 0.0131 |
| P11216b | Glycogen phosphorylase, brain form (PYGB) | 37.9 | 17.6 | 2.1 | 0.0135 |
| Q15413 | Ryanodine receptor 3 (RYR3) | 12.2 | 1.8 | 6.7 | 0.0164 |
| Q92598b | Heat shock protein 105 kDa (HSPH1) | 39.3 | 11.3 | 3.5 | 0.0169 |
| Q6PCE3b | Glucose 1,6-bisphosphate synthase (PG2L1) | 16.5 | 1.5 | 11.1 | 0.0190 |
| P16615b | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2, SERCA2) | 4.4 | 0.7 | 6.3 | 0.0194 |
| P00488 | Coagulation factor XIII A chain (F13A1) | 13.1 | 3.1 | 4.2 | 0.0232 |
| Q15904 | V-type proton ATPase subunit S1 (ATP6AP1) | 2.7 | 0.9 | 3.1 | 0.0235 |
| Q8IX18 | Probable ATP-dependent RNA helicase DHX40 (HX40) | 9.8 | 2.7 | 3.6 | 0.0240 |
| P22695b | Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) | 18.1 | 6.6 | 2.7 | 0.0241 |
| P54803 | Galactocerebrosidase (GALC) | 2.4 | 0.6 | 3.9 | 0.0270 |
| P11021 | 78 kDa glucose-regulated protein (HSPA5) | 108.0 | 68.2 | 1.6 | 0.0280 |
| Q9NQC3b | Reticulon-4 (RTN4) | 3.0 | 0.8 | 3.8 | 0.0304 |
| Q9HDC9 | Adipocyte plasma membrane-associated protein (APMAP) | 6.6 | 1.3 | 5.0 | 0.0308 |
| Q9NS86b | LanC-like protein 2 (LANCL2) | 5.3 | 0.4 | 12.4 | 0.0329 |
| O15394 | Neural cell adhesion molecule 2 (NCAM2) | 5.8 | 2.2 | 2.7 | 0.0344 |
| P63096 | Guanine nucleotide-binding protein G(i) subunit alpha-1 (GNAI1) | 2.3 | 0.9 | 2.7 | 0.0386 |
| P08107 | Heat shock 70 kDa protein 1A/1B (HSPA1A) | 63.9 | 21.8 | 2.9 | 0.0412 |
| O43813 | LanC-like protein 1 (LANCL1) | 6.7 | 3.2 | 2.1 | 0.0450 |
| P43004 | Excitatory amino acid transporter 2 (SLC1A2) | 16.6 | 6.5 | 2.6 | 0.0474 |
| P35579b | Myosin-9 (MYH9) | 4.2 | 1.0 | 4.5 | 0.0489 |
| P55290b | Cadherin-13 (CDH13) | 4.2 | 1.6 | 2.7 | 0.0498 |
a Similar protein regulated in DKO study (significant or black/white).
b Regulated in DKO study (significant or black/white).