Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Nov 26;13(2):580–593. doi: 10.1074/mcp.M113.035139

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

PMC Copyright notice

Fig. 6. — Indirect processing of PDGFRα and direct cleavage of ADAMTSL1 by MMP10. A, Domain structure of PDGFRα with annotated cleavage site in the extracellular domain, time-dependent abundance profile of the generated neo-N terminus, and characterization of processing by incubation of recombinant proteins and immunoblot analysis of MMP10-incubated secretomes. Lack of cleavage of recombinant PDGFRα by MMP10 indicates indirect cleavage in MMP10-incubated cell supernatants. B, Domain structure of ADAMTSL1 (isoform 1) with annotated cleavage site in an extended loop between thrombospondin domains (TS) 2 and 3, time-dependent abundance profile of the generated neo-N terminus, and validation of processing by incubation of recombinant proteins. Detection of MMP10-generated fragments with expected molecular weights by silver stain and immunoblot analysis identified ADAMTSL1 as a direct MMP10 substrate.