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Moderately differentiated pancreatobiliary type adenocarcinoma at the invasive margin. (A) Desmoplasia is prominent around the invasive tumor and tumor buds (H&E stain, ×100). (B) S100A4 is more highly expressed in invasive tumor cells than in noninvasive tumor cells (S100A4 immunostaining, ×100). (C) Membranous E-cadherin is more frequently lost in invasive tumor cells than in noninvasive tumor cells (E-cadherin immunostaining, ×100).
