Table I.
Metabolic and renal function parameters of diabetic-Wistar and SHR rats treated or not with CADO.
| Plasma glucose (mg/dL) | BW (g) | Food intake (g/24h) | Water intake (mL/24h) | U-excretion (mL/24h) | U-glucose (g/kg/24h) | U-proteins (mg/kg/24h) | GFR (mL/min) | FENa (%) | |
|---|---|---|---|---|---|---|---|---|---|
| Diabetic-Wistar | 590.5 ± 42.9 | 223.9 ± 7.5 | 37.8 ± 1.7 | 180.1 ± 15.4 | 197.7 ± 12.5 | 30.0 ± 2.4 | 197.0 ± 41.0 | 2.8 ± 0.6 | 0.57±0.06 |
| Diabetic-Wistar+CADO | 389.3 ± 23.0 | 237.4 ± 7.6 | 33.1 ± 1.8 | 162.9 ± 11.1 | 144.8 ± 10.2 | 18.5 ± 1.1 | 115.7 ± 9.4 | 2.8 ± 0.3 | 0.55±0.55 |
| P value | <0.05 | NS | NS | NS | <0.05 | <0.05 | <0.05 | NS | NS |
| Diabetic-SHR | 382.4 ± 44.4 | 176.8 ± 9.1 | 25.3 ± 1.3 | 125.7 ± 9.1 | 105.5 ± 9.7 | 23.4 ± 2.4 | 197.5 ± 24.2 | 2.0 ± 0.3 | 0.80±0.12 |
| Diabetic-SHR+CADO | 232.2 ± 51.0 | 195.5 ± 6.8 | 24.7 ± 1.0 | 114.9 ± 6.4 | 95.9 ± 5.3 | 13.2 ± 0.9 | 83.7 ± 12.6 | 1.6 ± 0.1 | 0.80±0.03 |
| P value | <0.05 | NS | NS | NS | NS | <0.05 | <0.05 | NS | NS |
Results expressed as mean ± SEM, n = 9–12 for all parameters (except GFR, n = 6–8).
BW = body weight; FENa = fractional excretion of Na+; GFR = glomerular filtration rate; NS = not significant; U = urine.