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. 2013 Aug 23;23(1):209–225. doi: 10.1093/hmg/ddt412

Figure 6.

Figure 6.

Isometric force generation in isolated 5th toes of the extensor digitorum longus (EDL). Bar graphs (mean ± SEM) represent the length (A), the PCSA (B), the average force (C) and the average isometric stress (D) of the fifth toe of isolated EDL muscles from 1- to 5–6-month-old WT and FHL1-null mice. Statistical analysis by two-way ANOVA (for differences in genotype and age) indicated an age- and genotype-dependent decrease in fiber length (#P < 0.01). The same analysis showed a genotype-dependent (but age-independent) increase in PCSA (*P < 0.01) and an age-dependent (but genotype-independent) decrease in average force generated (§P < 0.05). Finally, an age- and genotype-dependent decrease in average isometric stress was measured in FHL1-null EDL (#P < 0.01). N = 4 animals/8 muscles per group.