Table 2.
B-cell epitope regions of the 22 neutralizing antibodies.
| Binding site | Influenza A virus |
Influenza B virus |
|||
|---|---|---|---|---|---|
| Sa site | Near RBS | F subdomain | Stem base | Head base | |
| CROSS-REACTIVE NEUTRALIZING ANTIBODIES | |||||
| nAbs | 2D1 | C05 | CR6261 | CR8020 | CR8071 |
| 1F1 | 39.29 | CR8059 | |||
| 2G1 | C179 | ||||
| 8F8 | CR9114 | ||||
| 8M2 | F10 | ||||
| CH65 | FI6v3 | ||||
| CH67 | |||||
| S139/1 | |||||
| Binding site | Head base | RBS | Near RBS | ||
| X-31-SPECIFIC NEUTRALIZING ANTIBODIES | |||||
| nAbs | BH151 | HC19 | HC63 | ||
| HC45 | |||||
The nAbs are classified as cross-reactive or X-31-specific. For each binding region, a representative nAb was selected (shown in bold) and its B-cell epitope was mapped on the structures shown in Figure 3.