Table 3.

Somatostatin receptor subtype-binding affinity of somatostatin analogs.

Compound	SSTR1	SSTR2	SSTR3	SSTR4	SSTR5
RECEPTOR SUBTYPE AFFINITY (IC50, nM)
Somatostatin-14	2.26	0.23	1.43	1.77	0.88
Somatostatin-28	1.85	0.31	1.3	ND	0.4
Octreotide	1140	0.56	34	7030	7
Lanreotide	2330	0.75	107	2100	5.2
Pasireotide	9.3	1	1.5	>100	0.16

ND, not determined.

Modified from Ref. (20).