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. Author manuscript; available in PMC: 2015 Jan 17.
Published in final edited form as: J Org Chem. 2013 Dec 20;79(2):759–768. doi: 10.1021/jo402680v

Scheme 4.

Scheme 4

A. Preparation of Lys-protected S,S-tetrazine hexapeptide 9. B. Union of S,S-tetrazine hexapeptide 9 to the C-terminal peptide fragment 10 of the S,S-Tet-AKA target peptide, with the corresponding residue numbers shown, to furnish 18-mer 11.