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. Author manuscript; available in PMC: 2014 Dec 26.
Published in final edited form as: Oncogene. 2013 Aug 5;33(26):3422–3431. doi: 10.1038/onc.2013.308

Figure 4. Downregulation of MUC1-C suppresses HER2 activation in trastuzumab-resistant cells.

Figure 4

A and B. SKBR3R (A) and BT474R (B) cells were infected with lentiviruses expressing a control shRNA (CshRNA) or MUC1shRNA. Lysates were immunoblotted with the indicated antibodies. C and D. SKBR3R (C) and BT474R (D) cells were treated with 5 μM GO-203 for the indicated times. Anti-MUC1-C precipitates were immunoblotted with the indicated antibodies. E and F. SKBR3R (E) and BT474R (F) cells were treated with 5 μM GO-203 for the indicated times. Lysates were immunoblotted with the indicated antibodies.