Binnie 2007

Methods	Country: UK Recruitment: occurred in a single hospital‐based periodontal clinic Randomized controlled trial
Participants	118 smoking adults attending consultant clinics in an outpatient dental hospital periodontal clinic
Interventions	1. Intervention group ‐ 5 A's, NRT prn (patches, gum) 2. Usual care ‐ Received information regarding the role of tobacco in periodontal disease, 'very brief' advice to quit smoking
Outcomes	3, 6, 12m PP tobacco abstinence. Repeated PP (3, 6, 12m) used in analyses 12m cotinine measured for self reported quitters.
Notes	CO <8 ppm, COT <20 ng/ml cutoffs for quit status
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomization process was set up by the project statistician and was implemented independently from the recruitment process. After recruitment, the patient's name was transcribed into a log book containing sequential patient log numbers and the allocated hygienist.
Allocation concealment (selection bias)	Low risk	After allocating the patient to a hygienist, the patient was allocated to either intervention or control group using the minimization method.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Significant loss to follow‐up for both groups; 34/57 for control, 26/59 for intervention.