Table II.

HFS grading according to the National Cancer Institute Common Toxicity Criteria (NCI-CTC) version 4.0.

Severity	Criteria
Grade 1	Minimal skin changes or dermatitis (e.g., erythema, edema or hyperkeratosis) without pain
Grade 2	Skin changes (e.g., peeling, blisters, bleeding, edema or hyperkeratosis) with pain; limiting instrumental ADL
Grade 3	Severe skin changes (e.g., peeling, blisters, bleeding, edema or hyperkeratosis) with pain; limiting self care ADL

HFS, hand-foot syndrome; ADL, activities of daily living.