Table II.
Genotype distributions and allelic frequency of rs2230806 in the ATP-binding cassette A1 (ABCA1) gene.
| rs2230806 | Genotypes | In HWE chi-squarea | P-valueb | Deviation from HWE chi-squarea | P-valueb | ||
|---|---|---|---|---|---|---|---|
|
| |||||||
| Wild-type | Heterozygote | Homozygote | |||||
| CAD patients (n=120) | |||||||
| Observed (n) | 84 | 33 | 3 | 0.90 | NSc | 0.16 | NSb |
| Expected (n) | 84.17 | 32.66 | 3.17 | ||||
| Control subjects (n=100) | |||||||
| Observed (n) | 60 | 35 | 5 | 0.97 | NSb | 0.23 | NSb |
| Expected (n) | 60.06 | 34.88 | 5.06 | ||||
a
Pearson’s Chi-square at 1 degree of freedom.
b
Significant.
c
NS, not significant (the 5% significance level for 1 degree of freedom is = 3.84).
HWE, Hardy-Weinberg equilibrium. Test for Hardy-Weinberg Equilibrium and deviation from Hardy-Weinberg Equilibrium for single-nucleotide polymorphism significantly associated with coronary artery disease (CAD) occurrence.