Table IV.
Odds ratios (ORs) and confidence intervals (CIs) for carriers of rs2230806.
| Alleles | |||||
|---|---|---|---|---|---|
|
|
|||||
| Metabolic profile | AA | AG | GG | A | G |
| Controls, TG (mmol/l) | |||||
| Normal (%) | 30 (30) | 17 (17) | 10 (10) | 0.385 | 0.185 |
| High (%) | 23 (23) | 18 (18) | 2 (2) | 0.32 | 0.11 |
| Patients, TG (mmol/l) | |||||
| Normal | 32 (26.6) | 51 (42.5) | 9 (0.075) | 0.479 | 0.287 |
| High | 17 (14.1) | 11 (9.1) | 0.187 | 0.045 | |
| OR of GG genotypes vs AA+AG, (95% CI), P-value | 2.362 (0.9055–6.161), 0.08 | ||||
| Controls, TC (mmol/l) | |||||
| Normal (%) | 14 (14) | 35 (35) | 26 (26) | 0.216 | 0.381 |
| High (%) | 8 (8) | 9 (9) | 8 (8) | 0.125 | 0.125 |
| Patients, TC (mmol/l) | |||||
| Normal (%) | 53 (44.1) | 21 (17.5) | 22 (18.2) | 0.528 | 0.27 |
| High (%) | 13 (10.8) | 3 (2.5) | 8 (6.6) | 0.12 | 0.079 |
| OR of GG genotypes vs. AA+AG, (95% CI), P-value | 0.6182 (0.3073–1.244), 0.2158 | ||||
| Controls, HDL-C (mmol/l) | |||||
| Normal (%) | 53 (53) | 26 (26) | 7 (7) | 0.66 | 0.2 |
| High (%) | 5 (5) | 5 (5) | 4 (4) | 0.075 | 0.065 |
| Patients, HDL-C (mmol/l) | |||||
| Normal (%) | 20 (16.6) | 73 (60.8) | 13 (10.7) | 0.48 | 0.411 |
| High (%) | 6 (5) | 5 (4.1) | 3 (2.5) | 0.07 | 0.045 |
| OR of GG genotypes vs. AA+AG, (95%CI), P-value | 1.730 (0.7222–4.143), 0.0247 | ||||
| Controls, LDL-C (mmol/) | |||||
| Normal (%) | 23 (23) | 60 (60) | 5 (5) | 0.475 | 0.455 |
| High (%) | 8 (8) | 4 (4) | 0 (0) | 0.10 | 0.04 |
| Patients, LDL-C (mmol/l) | |||||
| Normal (%) | 65 (45.1) | 19 (15.7) | 9 (7.5) | 0.62 | 0.153 |
| High (%) | 8 (6.6) | 15 (12.5) | 4 (3.3) | 0.129 | 0.095 |
| OR of GG genotypes vs. AA+AG, (95% CI), P-value | 0.2043 (0.06718–0.6215), 0.0039 | ||||
Data are presented as percentages, unless otherwise specified. The odds ratios were calculated by using the wild-type genotype as the reference group. The odds ratios for coronary artery disease (CAD)-associated genotypes with lipid parameters for CAD patient samples versus controls demonstrated a significant association of lower high-density lipoprotein-C (HDL-C) levels with GG genotypes. LDL-C, low-density lipoprotein-C.