Table II.
Estimated sensitivity, specificity and DOR of REA, CLIA and their combinations regarding TK1.
| Estimate | 95% CI | |||||
|---|---|---|---|---|---|---|
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| Parameter | Total | CLIA | REA | Total | CLIA | REA |
| Sensitivity | 0.601 | 0.519 | 0.643 | 0.497–0.696 | 0.436–0.601 | 0.424–0.815 |
| Specificity | 0.882 | 0.949 | 0.891 | 0.790–0.936 | 0.889–0.978 | 0.798–0.944 |
| Positive likelihood ratio | 5.072 | 10.229 | 5.902 | 2.979–8.635 | 5.171–20.234 | 3.521–9.893 |
| Negative likelihood ratio | 0.453 | 0.506 | 0.401 | 0.363–0.564 | 0.440–0.583 | 0.236–0.680 |
| Diagnostic score | 2.416 | 3.005 | 2.690 | 1.836–2.997 | 2.395–3.616 | 1.968–3.412 |
| DOR | 11.202 | 20.196 | 14.734 | 6.268–20.020 | 10.966–37.195 | 7.159–30.325 |
| ROC area, AUC | 0.80 | 0.75 | 0.88 | 0.76–0.83 | 0.71–0.78 | 0.85–0.91 |
DOR, diagnostic odds ratio; REA, radioenzymatic assay; CLIA, chemiluminescence immunoassay; TK1, thymidine kinase; ROC, receiver operating characteristic; AUC, area under the curve.