Table II.
DNMT3B-149C>T genotype and allele frequency and distribution.
| A, DNMT3B-149C>T genotype and allele frequency among cases and controls | ||||||
|---|---|---|---|---|---|---|
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| HCC (n=108) | Control subjects (n=216) | |||||
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| Genotype/allele | No. | (%) | No. | (%) | Crude OR (95% CI) | P-valuea |
| Genotype | ||||||
| TT | 107 | 99.07 | 210 | 97.22 | 1 | |
| CT | 1 | 0.93 | 6 | 2.78 | 0.327 (0.039–2.752) | 0.499b |
| CC | 0c | 0.00 | 0 | 0.00 | - | |
| Allele | ||||||
| C | 1 | 0.46 | 6 | 1.39 | 1 | |
| T | 215 | 99.54 | 426 | 98.61 | 3.028 (0.362–25.313) | 0.502d |
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| B, Distribution of-149C>T DNMT3B genotypes and association with age and gender in HCC cases | ||||||
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| Genotype | Allele | |||||
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| Groups | CC (%) | CT (%) | TT (%) | T (%) | P-valuee | |
|
| ||||||
| Age (years) | 0 (0.00) | 1 (0.93) | 107 (99.07) | 99.07 | ||
| <50 | 0 (0.00) | 0 (0.00) | 35 (32.40) | 100.00 | 1.000f | |
| ≥50 | 0 (0.00) | 1 (10.93) | 72 (66.67) | 98.63 | ||
| Gender | ||||||
| Male | 0 (0.00) | 0 (0.00) | 85 (78.70) | 100.00 | 0.213g | |
| Female | 0 (0.00) | 1 (0.93) | 22 (20.37) | 95.65 | ||
a
Chi-square (χ2) test;
b
HCC cases vs. controls;
c
CC genotype not detected in HCC patients and control subjects;
d
T allele vs. C allele;
e
Chi-square (χ2) test;
f
frequency of the T allele in individuals aged <50 vs. ≥50 years;
g
frequency of the T allele in male vs. female individuals.
DNMT3B, DNA methyltransferase 3B; HCC, hepatocellular carcinoma; OR, odds ratio; CI, confidence interval.