Table II.
Meta-analysis of FAS/FASL polymorphisms and cervical cancer risk.
| Variables | Na | G vs. A | GG vs. AA | GA vs. AA | GG/GA vs. AA | GG vs. GA/AA | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
|
|
|
|||||||
| OR (95% CI) | P-valueb | OR (95% CI) | P-valueb | OR (95% CI) | P-valueb | OR (95% CI) | P-valueb | OR (95% CI) | P-valueb | ||
| FAS-670 A/G | |||||||||||
| Overall | 10 | 1.016 (0.898–1.149)c | 0.028 | 0.944 (0.729–1.222) | 0.058 | 1.034 (0.768–1.393) | 0.000 | 1.043 (0.797–1.366) | 0.000 | 0.999 (0.784–1.274) | 0.004 |
| Studies with HWE | 8 | 0.984 (0.860–1.125) | 0.029 | 0.960 (0.727–1.267) | 0.034 | 0.911 (0.711–1.167) | 0.010 | 0.932 (0.738–1.176) | 0.012 | 1.019 (0.828–1.254) | 0.078 |
| Ethnicity | |||||||||||
| Asian | 6 | 0.996 (0.815–1.217) | 0.009 | 0.909 (0.595–1.386) | 0.020 | 1.011 (0.660–1.547) | 0.000 | 1.032 (0.695–1.531) | 0.000 | 0.931 (0.590–1.469) | 0.001 |
| Mixed | 2 | 0.996 (0.822–1.206) | 0.547 | 0.897 (0.601–1.340) | 0.347 | 0.915 (0.459–1.824) | 0.084 | 0.892 (0.624–1.275) | 0.131 | 1.061 (0.806–1.396) | 0.794 |
| Source of controls | |||||||||||
| PB | 4 | 0.998 (0.795–1.254) | 0.018 | 0.981 (0.610–1.577) | 0.022 | 1.005 (0.718–1.408) | 0.041 | 0.997 (0.712–1.397) | 0.027 | 0.991 (0.671–1.464) | 0.030 |
| HB | 6 | 1.002 (0.892–1.124) | 0.127 | 0.880 (0.680–1.138) | 0.268 | 1.097 (0.646–1.864) | 0.000 | 1.112 (0.699–1.770) | 0.001 | 1.001 (0.703–1.424) | 0.013 |
| FAS-1377 G/A | |||||||||||
| A vs. G | AA vs. GG | AG vs. GG | AA/AG vs. GG | AA vs. AG/GG | |||||||
| Overall | 5 | 0.993 (0.880–1.122) | 0.254 | 1.000 (0.757–1.322) | 0.402 | 0.926 (0.781–1.097) | 0.153 | 0.950 (0.808–1.117) | 0.167 | 1.105 (0.853–1.432) | 0.492 |
| Ethnicity | |||||||||||
| Asian | 3 | 0.952 (0.830–1.092) | 0.195 | 0.949 (0.701–1.284) | 0.201 | 0.854 (0.699–1.044) | 0.149 | 0.879 (0.726–1.063) | 0.165 | 1.076 (0.814–1.420) | 0.215 |
| Source of controls | |||||||||||
| HB | 4 | 1.000 (0.860–1.162) | 0.150 | 1.043 (0.747–1.458) | 0.279 | 0.878 (0.710–1.085) | 0.111 | 0.925 (0.756–1.131) | 0.100 | 1.201 (0.882–1.634) | 0.480 |
| FASL -844 T/C | |||||||||||
| C vs. T | CC vs. TT | TC vs. TT | CC/TC vs. TT | CC vs. TC/TT | |||||||
| Overall | 6 | 1.116 (0.914–1.364) | 0.006 | 1.168 (0.903–1.510) | 0.165 | 1.111 (0.896–1.378) | 0.858 | 1.131 (0.922–1.385) | 0.445 | 1.114 (0.829–1.498) | 0.008 |
| Studies with HWE | 5 | 1.007 (0.895–1.134) | 0.656 | 0.994 (0.749–1.319) | 0.863 | 1.074 (0.856–1.347) | 0.892 | 1.055 (0.851–1.308) | 0.850 | 0.982 (0.829–1.162) | 0.722 |
| Ethnicity | |||||||||||
| Asian | 3 | 1.221 (0.877–1.699) | 0.012 | 1.215 (0.714–2.068) | 0.171 | 1.266 (0.823–1.949) | 0.801 | 1.477 (0.979–2.229) | 0.387 | 1.269 (0.825–1.952) | 0.005 |
| Source of controls | |||||||||||
| PB | 2 | 1.235 (0.713–2.139) | 0.000 | 1.503 (0.501–4.504) | 0.010 | 1.113 (0.751–1.649) | 0.294 | 1.332 (0.590–3.010) | 0.052 | 1.306 (0.656–2.599) | 0.000 |
| HB | 4 | 1.048 (0.904–1.214) | 0.648 | 1.061 (0.744–1.513) | 0.815 | 1.110 (0.859–1.436) | 0.842 | 1.099 (0.861–1.403) | 0.824 | 1.029 (0.823–1.287) | 0.644 |
a
Number of comparisons.
b
P-value of Q-test for heterogeneity test.
c
Random effects model was used when P value for heterogeneity test was 0.05, otherwise the fixed effects model was used. HB, hospital based case control study; PB, population based case control study; OR, odds ratio; 95% CI, 95% confidence interval.